How Tumor Cells Move

Researchers in Heidelberg discover new protein that is suppressed in particularly aggressive cancer cell.If cancer cells lack a certain protein, it could be much easier for them to penetrate healthy body tissue, the first step towards forming metastases. Scientists at the Pharmacology Institute of the University of Heidelberg have discovered the previously unknown cell signal factor SCAI (suppressor of cancer cell invasion), which inhibits the movement and spread of tumor cells in laboratory tests. When the factor’s functioning was disrupted, the cancer cells moved much more effectively in what are known as three-dimensional matrix systems, which imitate some of the tissue properties of the human body.

“The protein is apparently suppressed in many types of tumors, e.g. breast, lung, or thyroid,” explains Dr. Robert Grosse, head of the Emmy Noether Junior Research Group funded by the German Research Association (DFG) at the Pharmacology Institute. The new factor could be an interesting starting point for research into new mechanisms for fighting cancer. The research team’s results have now been published online in the prestigious international journal Nature Cell Biology.

Focus on particularly aggressive cancers

Tumor cells are extremely mobile and “adept” at penetrating healthy tissue to form metastases. They adapt to the consistency of the respective tissue by changing their shapes constantly and attach flexibly to surrounding tissues during movement with the help of special surface structures (receptors).

One of these receptors is what is known as b1-integrin, which is frequently formed in many tumors such as metastasizing breast cancer. “The cell signal factor SCAI controls the formation and function of b1-integrin,” says Dr. Robert Grosse. “If there is too little SCAI in tumor cells, then b1-integrin is overactive, so to speak. The cell can change more rapidly to a more aggressive form and penetrate surrounding tissue, a crucial step toward increased spreading of the tumor and the possible formation of metastases.”

In their recently published study, the Heidelberg researchers examined cells from skin cancer (melanoma) and breast cancer. In other projects, Dr. Robert Grosse’s team would like to study the function of the signal factor SCAI more closely in an animal model. “If the function of SCAI is confirmed to be decisive in the formation of especially aggressive tumor cells, this could be a promising starting point for developing new diagnostic methods or medication,” says the pharmacologist. It could also be possible to develop an agent that prevents the genetic suppression of the signal factor in cancer cells. But first the researchers need to better understand how the signal factor itself is regulated in the cell.

Dance Your Way To Successful Aging

Older people can dance their way towards improved health and happiness, according to a report from the Changing Ageing Partnership (CAP).The research, by Dr Jonathan Skinner from Queen’s University Belfast, reveals the social, mental and physical benefits of social dancing for older people. It suggests that dancing staves of illness, and even counteracts decline in ageing.

Recommendations include the expansion of social dance provision for older people in order to aid successful ageing and help older people enjoy longer and healthier lives.

Jonathan Skinner, Lecturer in Social Anthropology at the School of History and Anthropology at Queen’s, studied the effects of social dancing amongst older people in Northern Ireland, Blackpool and Sacramento, USA.

Dr Skinner said: "I have found that social dancing leads to a continued engagement with life - past, present, and future - and holds the promise for successful ageing. It contributes to the longevity of the dancers, giving them something to enjoy and focus upon - to live for. It alleviates social isolation and quite literally helps take away the aches and pains associated with older age.

“In addition to this, and especially in Northern Ireland, dancing brings people together across communities, creating solidarity, tolerance and understanding."

Sarah, a 70-year-old from Bangor and a regular ice-dancer, took part in the study. Sarah said: "My daughters brought me down to the ice rink. I have to say, after years of dancing on a Ballroom floor, I was very impressed and skating has great flow and speed. I’ve been doing it for twelve years now. We do the rumba, quickstep, foxtrot and tango. My instructor even wanted me to compete. My friends have commented that my energy is overwhelming, ‘what’s the secret?’ they ask, and I just say ‘keep dancing’.”

Dr Una Lynch, CAP Research Manager at Queen’s said: "Dr Skinner's study is the seventh piece of CAP research to be completed and we are delighted to be involved in a study that challenges stereotypical images of ageing and highlights the fact that healthy ageing can be fun."

The researcher, Jonathan Skinner, will present further findings and recommendations of the research at a research launch at the Institute of Governance at Queen’s University Belfast on Wednesday 1 April.